Meta-Analysis and Structural Dynamics of the Emergence of Genetic Variants of SARS-CoV-2

Graphical Abstract Errors are regularly made when SARS-CoV-2 replicates its RNA genome. The viral polymerase complex is error-prone with imperfect proofreading abilities. These errors or mutations often lead to deleterious neutral effects on the virus. However, sometimes these have a positive effect and create genetic variants of virus different features including increased transmissibility, pathogenicity, immune escape capabilities. When work collaboratively new feature, this called epistasis.